Plasma Hemoglobin-Binding Capacity in Sickle Cell Disease

Plasma hemoglobin-binding capacity in sickle cell disease.

T HE PLASMA PROTEINS of all but a small percentage of normal mdi-viduals possess the property of forming a complex with and of binding extracorpuscular hemoglobin. The capacity of these proteins, vhich have tentatively been identified as alpha-2-globulins,1 to bind hemoglobin is limited. Under in vitro and in vivo circumstances, hemoglobin may be bound in a concentration up to approximately 125...

Steady state hemoglobin concentration and packed cell volume in homozygous sickle cell disease patients in Lagos, Nigeria

Background: Sickle cell disease is a genetic disorder of hemoglobin causing myriad of pathology including anemia. The purpose of this study was to evaluate the baseline values of steady state hemoglobin and packed cell volume as a guide to managing the early recognition of hemolytic crises in sickle cell anemia. Methods: A cross-sectional study was conducted among the sickle cell patients atte...

Intraerythrocytic Hemoglobin Crystals in Sickle Cell-hemoglobin C Disease.

sickle cell hemoglobin d disease first reported case in iran

a case of sickle cell hb d disease is reported in  young iranian male. the father of whom carried an as sickle cell trait and the mother an ad trait. this disease was diagnosed by hb electrophoresis. agar gel electrophoresis sickling and solubility tests.this is the first case of sickle cell hb d disease reported in iran.

Intracardiac Thrombosis in Sickle Cell Disease

In patients with sickle cell disease, thrombotic microangiopathy is a rare complication. Also in sickle cell disease, intracardiac thrombus formation without structural heart diseases or atrial arrhythmias is a rare phenomenon. We herein describe a 22-year-old woman, who was a known case of sickle cell-βthalassemia, had a history of recent missed abortion, and was admitted with a vaso-occlusive...